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. 2018 Jul 5;8:10175. doi: 10.1038/s41598-018-28490-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Diminazene aceturate (DIZE) treatment inhibited hepatocyte necrosis in BDL mice. H&E stained liver sections (A) (×40) showed more than 50% reduction in hepatocyte necrosis in DIZE treated BDL mice compared to saline treated BDL mice. (B) This reduction was associated in BDL but not in Mdr2-KO mice with a reduced expression of hepatic TNF-α. (C) Treatment with DIZE inhibited both gene expression (D) and protein secretion (E) of TNF-α by lipopolysaccharide (LPS)-stimulated Kupffer cells (KUP5 cells). Each bar represents the mean ± SEM profile from 10–15 mice (panel B,C) or 3 independent experiments (panels D,E) per treatment group. Arrows in panel A indicate necrotic patches in BDL mice.