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. 2018 Jul 5;8:10222. doi: 10.1038/s41598-018-28528-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RNA editing hotspots in LUAD and LUSC tissue samples. (a) Diagram showing the distribution of all detected editing hotspots across miRNA nucleotide positions. (b) Venn diagram of RNA editing hotspots in LUAD and LUSC samples, showing that the majority of editing hotspots is shared. (c,d) Statistics for miRNA editing hotsposts and WT counterparts in normal and tumor samples for both LUAD and LUSC. Hotsposts occurring within MSRs are in light blue, while those outside the MSR are in light orange. P-values were calculated with the following methods respectively: Mann-Withney paired test for editing level; paired t-test for ED\WT miRNA expression; Pearson correlation test between WT\ED miRNA expressions. Significant P-values (P < 0.05) are in green.