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. 2018 Jun 29;9:1495. doi: 10.3389/fimmu.2018.01495

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Copyright © 2018 Lin, Huang, Wu, Liu, Chen, Ma, Zhang, Liu, Huang, Li, Zhang, Hou, Yang, Lu and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Application of toll-like receptor 2 ligand P3C at a late time point after hydrodynamic injection (HI) does not inhibit hepatitis B virus (HBV) replication in the model for persistent HBV replication. C57BL/6 mice received (HI) with plasmid pAAV-HBV1.2. These mice were then treated three times with 50 µg of P3C or phosphate-buffered saline administered by subcutaneous (SC) injection at day 14, 21, and 28 (D14). (A) Serological markers of HBV infection HBsAg, Hepatitis B e antigen (HBeAg), and HBV DNA were assayed at the indicated time points. (B) Positivity for HBsAg or HBeAg was defined as ≥1. (C) The serum levels of anti-HBs and anti-HBc antibodies were also detected at the indicated time points. Seven mice were analyzed per group, and the experiments were repeated at least once. Data were analyzed using an unpaired Student’s t test. Statistically significant differences between the groups are indicated as *P < 0.05 and **P < 0.01.