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. 2018 Jun 29;9:344. doi: 10.3389/fendo.2018.00344

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Copyright © 2018 Adamik, Silbermann, Marino, Sun, Anderson, Zhou, Xie, Roodman and Galson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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XRK3F2 prevents MM-induced decrease of H3K9ac at the Runx2 promoter by blocking the recruitment of GFI1 and histone deacetylase HDAC1. (A) Schematic representation of the murine Runx2 gene and positions of amplicons used for ChIP-qPCR analysis. Shown are ChIP data for (B) GFI1, (C) HDAC1 binding and (D) H3K9ac levels at the Runx2-P1 promoter in MC4 preOB after 48 h in proliferation media control (d0), control treated with 5 μM XRK3F2 (d0+XRK3F2), 5TGM1-MM-treated (d0+MM), and 5TGM1-MM-treated in the presence of XRK3F2 (d0+MM+XRK3F2). IgG non-specific control was subtracted in the H3K9ac data set. SEM represents 2 (for GFI1 and HDAC1) and 3 (for H3K9ac) biological replicates. ^*p ≤ 0.05; ^**p ≤ 0.01.