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. 2018 Jun 29;9:344. doi: 10.3389/fendo.2018.00344

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Copyright © 2018 Adamik, Silbermann, Marino, Sun, Anderson, Zhou, Xie, Roodman and Galson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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XRK3F2 rescues expression of osteogenic genes in MM-exposed preOB. (A) As depicted in the experimental design schematic, MC4 cells were cultured with or without 5TGM1 MM cells (in a direct contact) for 48 h under proliferation conditions. MM cells were then removed by washing (d0) and media was changed to osteogenic conditions +/– XRK3F2 (2.5, 5 μM) for 4 days (d4). MC4 cells were harvested at both d0 and d4 for mRNA analyses. qPCR mRNA profiles for (B) Runx2, (C) Ocn, (D) Bsp, (E) Osx, (F) Gfi1, (G) Il6, and (H) Vcam1 are shown. SEM for 3 experimental wells and a representative of 2 biological replicates are shown. ^*p ≤ 0.05; ^**p ≤ 0.01.