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. 2018 Jun 29;8:246. doi: 10.3389/fonc.2018.00246

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Copyright © 2018 Poluri and Audet-Walsh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Copy number alteration (CNA) is the most frequent inactivation mechanism of PTEN in human prostate cancer (PCa). (A) Genomic alterations of the PTEN gene in PCa. Only cohorts with data on both mutation and CNAs are shown. Abbreviations: NEPC, neuroendocrine prostate cancer; CRPC, castration-resistant PCa. (B) Specific alterations of PTEN in the Michigan (MICH), Fred Hutchinson Cancer Research Center (FHCRC), Stand Up To Cancer (SU2C), and The Cancer Genome Atlas (TCGA) cohorts. Note that the proportion of alterations is slightly different than in (A): all tumors are shown in (A) while all patients are shown in (B) (some patients had more than one sample sequenced).