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. 2018 May 23;14:150–157. doi: 10.1016/j.molmet.2018.05.014

Figure 1.

Figure 1

Analysis of atherosclerotic lesions in C57BL6 ApoE−/− mice after viral overexpression of GIP (1–42). Model to illustrate study protocol (A), serum total GIP concentrations 21 days after viral overexpression (B), body weight (C), oral glucose tolerance test 14 weeks after viral overexpression (D), final serum lipid measurement 16 weeks after viral overexpression (E, F) (n = 5–10). Results are expressed as the mean ± SEM. ***p < 0.001 vs. LacZ. Quantification of atherosclerotic plaque burden in the descending aorta (G) and the aortic root (H), representative pictures and respective quantification displayed by scatter plots of lesion extents visualized by H&E staining (I), macrophage content visualized by MOMA-2 staining (J), MMP-9 expression (K) and collagen content visualized by picrosirius red staining (L) in the aortic root (H–K) and aortic arch (L), linear regression analysis between plaque MOMA-2 expression and plaque collagen content (M) (n = 5–10). Results are expressed as the mean ± SEM. *p < 0.05 and **p < 0.01 vs. LacZ.