Table 2A.

Correlation of N-acylethanolamine (NAE) circulating levels (A) and their ratios (B) with metabolic parameters evaluated in the overall premenopausal and menopausal cohorts and within body mass index (BMI) classes. Data are shown as P values (sign of the coefficients) of the correlations (non italic data) as well as of the effects of BMI, menopause (MP) and their interaction on correlations (italic data). Significant P values are reported in bold.

Metabolic parameter	Cohort	Overall			BMI classes									Effect of BMI¥
					Normal weight (NW)			Overweight (OW)			Obese (OB)
		AEA	PEA	OEA	AEA	PEA	OEA	AEA	PEA	OEA	AEA	PEA	OEA	AEA	PEA	OEA
Waist circumference	Premenopausal	0.011 (+)	0.889 (−)	0.632 (+)	0.180 (+)	0.976 (+)	0.646 (−)	0.051 (+)	0.785 (−)	0.373 (+)	0.245 (+)	0.971 (+)	0.890 (+)	0.773 (+)	0.988 (+)	0.722 (+)
	Menopausal	0.001 (+)	0.040 (+)	0.080 (+)	0.054 (+)	0.389 (+)	0.259 (+)	0.020 (+)	0.050 (+)	0.286 (+)	0.146 (+)	0.531 (+)	0.356 (+)	0.909 (+)	0.974 (+)	0.899 (+)
	MP effectπ	0.373 (+)	0.094 (+)	0.296 (+)	0.491 (+)	0.510 (+)	0.242 (+)	0.544 (+)	0.089 (+)	0.779 (+)	0.741 (+)	0.654 (+)	0.548 (+)	0.921 (−)&	0.988 (+)&	0.893 (−)&
SBP	Premenopausal	0.102 (+)	0.371 (+)	0.036 (+)	0.549 (+)	0.958 (−)	0.475 (+)	0.276 (+)	0.730 (+)	0.217 (+)	0.277 (+)	0.238 (+)	0.105 (+)	0.625 (+)	0.336 (+)	0.399 (+)
	Menopausal	0.465 (+)	0.131 (+)	0.132 (+)	0.403 (+)	0.018 (+)	0.002 (+)	0.552 (−)	0.347 (−)	0.376 (−)	0.428 (+)	0.324 (+)	0.656 (+)	0.879 (+)	0.553 (−)	0.151 (−)
	MP effectπ	0.488 (−)	0.698 (+)	0.619 (−)	0.836 (+)	0.076 (+)	0.078 (+)	0.216 (−)	0.425 (−)	0.130 (−)	0.916 (−)	0.986 (−)	0.471 (−)	0.834 (−)&	0.280 (−)&	0.103 (−)&
DBP	Premenopausal	0.018 (+)	0.062 (+)	0.152 (+)	0.532 (+)	0.241 (+)	0.360 (+)	0.228 (+)	0.322 (+)	0.600 (+)	0.018 (+)	0.194 (+)	0.182 (+)	0.129 (+)	0.739 (+)	0.604 (+)
	Menopausal	0.985 (+)	0.325 (+)	0.423 (+)	0.963 (+)	0.120 (+)	0.083 (+)	0.368 (−)	0.322 (−)	0.550 (−)	0.379 (+)	0.396 (+)	0.982 (+)	0.534 (+)	0.552 (−)	0.190 (−)
	MP effectπ	0.078 (−)	0.453 (−)	0.587 (−)	0.698 (−)	0.525 (+)	0.351 (+)	0.135 (−)	0.176 (−)	0.451 (−)	0.290 (−)	0.750 (−)	0.336 (−)	0.618 (−)&	0.503 (−)&	0.181 (−)&
Glucose	Premenopausal	0.433 (+)	0.381 (+)	0.235 (+)	0.421 (−)	0.555 (−)	0.850 (−)	0.217 (+)	0.230 (+)	0.230 (+)	0.718 (+)	0.671 (+)	0.467 (+)	0.414 (+)	0.475 (+)	0.507 (+)
	Menopausal	0.387 (+)	0.149 (+)	0.418 (+)	0.038 (+)	0.022 (+)	0.061 (+)	0.174 (−)	0.593 (−)	0.271 (−)	0.631 (+)	0.588 (+)	0.705 (+)	0.279 (−)	0.236 (−)	0.309 (−)
	MP effectπ	0.882 (−)	0.916 (+)	0.605 (−)	0.044 (+)	0.045 (+)	0.150 (+)	0.093 (−)	0.189 (−)	0.123 (−)	0.941 (+)	0.943 (+)	0.786 (−)	0.181 (−)&	0.182 (−)&	0.238 (−)&
Insulin	Premenopausal	0.281 (+)	0.800 (−)	0.912 (−)	0.056 (+)	0.074 (+)	0.397 (+)	0.918 (+)	0.612 (−)	0.707 (−)	0.545 (+)	0.385 (−)	0.831 (−)	0.629 (−)	0.095 (−)	0.534 (−)
	Menopausal	0.491 (+)	0.807 (−)	0.386 (−)	0.423 (+)	0.460 (−)	0.198 (−)	0.591 (+)	0.459 (+)	0.752 (+)	0.957 (−)	0.732 (−)	0.623 (−)	0.575 (−)	0.827 (+)	0.643 (+)
	MP effectπ	0.827 (−)	0.992 (−)	0.571 (−)	0.802 (−)	0.127 (−)	0.125 (−)	0.807 (+)	0.394 (+)	0.624 (+)	0.676 (−)	0.786 (+)	0.801 (−)	0.858 (−)&	0.252 (+)&	0.461 (+)&
HOMA-IR	Premenopausal	0.228 (+)	0.968 (−)	0.820 (+)	0.096 (+)	0.147 (+)	0.421 (+)	0.723 (+)	0.858 (−)	0.943 (−)	0.570 (+)	0.450 (−)	0.977 (−)	0.689 (−)	0.160 (−)	0.656 (−)
	Menopausal	0.435 (+)	0.820 (+)	0.619 (−)	0.191 (+)	0.909 (+)	0.642 (−)	0.976 (−)	0.663 (+)	0.910 (−)	0.900 (+)	0.922 (−)	0.777 (−)	0.457 (−)	0.882 (−)	0.936 (+)
	MP effectπ	0.767 (−)	0.849 (+)	0.608 (−)	0.875 (+)	0.476 (−)	0.405 (−)	0.762 (−)	0.687 (+)	0.992 (−)	0.774 (−)	0.665 (+)	0.849 (−)	0.746 (−)&	0.439 (+)&	0.730 (+)&
Total cholesterol	Premenopausal	0.157 (+)	0.154 (+)	0.036 (+)	0.081 (+)	0.006 (+)	0.008 (+)	0.289 (+)	0.703 (−)	0.530 (+)	0.910 (+)	0.305 (+)	0.270 (+)	0.449 (−)	0.636 (−)	0.741 (−)
	Menopausal	0.455 (−)	0.069 (+)	0.081 (+)	0.467 (+)	<0.001 (+)	<0.001 (+)	0.924 (+)	0.632 (+)	0.629 (+)	0.092 (−)	0.965 (−)	0.543 (−)	0.072 (−)	0.049 (−)	0.005 (−)
	MP effectπ	0.152 (−)	0.519 (+)	0.855 (+)	0.812 (−)	0.112 (+)	0.027 (+)	0.544 (−)	0.541 (+)	0.975 (−)	0.148 (−)	0.533 (−)	0.258 (−)	0.276 (−)&	0.166 (−)&	0.032 (−)&
HDL-cholesterol	Premenopausal	0.912 (+)	0.097 (+)	0.358 (+)	0.708 (−)	0.237 (+)	0.647 (+)	0.855 (−)	0.454 (+)	0.814 (+)	0.331 (+)	0.132 (+)	0.175 (+)	0.328 (+)	0.716 (+)	0.465 (+)
	Menopausal	0.596 (+)	0.053 (+)	0.043 (+)	0.293 (+)	0.010 (+)	0.022 (+)	0.364 (+)	0.410 (+)	0.281 (+)	0.402 (−)	0.896 (−)	0.883 (+)	0.182 (−)	0.053 (−)	0.124 (−)
	MP effectπ	0.789 (+)	0.973 (+)	0.513 (+)	0.275 (+)	0.115 (+)	0.088 (+)	0.596 (+)	0.721 (−)	0.829 (+)	0.212 (−)	0.319 (−)	0.491 (−)	0.099 (−)&	0.071 (−)&	0.093 (−)&
Triglycerides	Premenopausal	0.693 (+)	0.795 (−)	0.916 (+)	0.110 (+)	0.181 (+)	0.148 (+)	0.409 (+)	0.734 (−)	0.913 (−)	0.096 (−)	0.258 (−)	0.409 (−)	0.022 (−)	0.086 (−)	0.122 (−)
	Menopausal	0.010 (+)	0.005 (+)	0.043 (+)	0.067 (+)	0.023 (+)	0.010 (+)	0.383 (+)	0.416 (+)	0.763 (+)	0.067 (+)	0.050 (+)	0.283 (+)	0.391 (+)	0.437 (+)	0.876 (−)
	MP effectπ	0.076 (+)	0.017 (+)	0.130 (+)	0.762 (+)	0.417 (+)	0.337 (+)	0.860 (−)	0.457 (+)	0.793 (+)	0.017 (+)	0.024 (+)	0.181 (+)	0.054 (+)&	0.119 (+)&	0.491 (+)&