Table 2B.
| Metabolic parameter | Cohort | Overall |
BMI classes |
Effect of BMI¥ |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Normal weight (NW) |
Overweight (OW) |
Obese (OB) |
||||||||||||||
| PEA/AEA | OEA/AEA | OEA/PEA | PEA/AEA | OEA/AEA | OEA/PEA | PEA/AEA | OEA/AEA | OEA/PEA | PEA/AEA | OEA/AEA | OEA/PEA | PEA/AEA | OEA/AEA | OEA/PEA | ||
| Waist circumference | Premenopausal | <0.001 (−) | <0.001 (−) | 0.366 (+) | 0.039 (−) | 0.014 (−) | 0.321 (−) | 0.001 (−) | 0.210 (−) | 0.042 (+) | 0.040 (−) | 0.015 (−) | 0.987 (−) | 0.501 (−) | 0.417 (−) | 0.616 (+) |
| Menopausal | 0.009 (−) | 0.012 (−) | 0.817 (+) | 0.049 (−) | 0.194 (−) | 0.431 (+) | 0.222 (−) | 0.055 (−) | 0.384 (−) | 0.115 (−) | 0.258 (−) | 0.433 (+) | 0.846 (−) | 0.840 (−) | 0.838 (+) | |
| MP effectπ | 0.478 (+) | 0.821 (+) | 0.689 (−) | 0.788 (−) | 0.606 (+) | 0.218 (+) | 0.279 (+) | 0.467 (−) | 0.052 (−) | 0.867 (+) | 0.435 (+) | 0.549 (+) | 0.774 (+)& | 0.709 (+)& | 0.865 (−)& | |
| SBP | Premenopausal | 0.130 (−) | 0.835 (+) | 0.013 (+) | 0.354 (−) | 0.980 (+) | 0.210 (+) | 0.203 (−) | 0.970 (+) | 0.071 (+) | 0.685 (−) | 0.767 (+) | 0.221 (+) | 0.801 (+) | 0.827 (+) | 0.845 (+) |
| Menopausal | 0.602 (+) | 0.594 (+) | 0.613 (+) | 0.163 (+) | 0.015 (+) | 0.029 (+) | 0.890 (−) | 0.816 (−) | 0.813 (−) | 0.844 (−) | 0.374 (−) | 0.463 (−) | 0.329 (−) | 0.032 (−) | 0.061 (−) | |
| MP effectπ | 0.144 (+) | 0.831 (+) | 0.140 (−) | 0.099 (+) | 0.075 (+) | 0.448 (+) | 0.318 (+) | 0.875 (−) | 0.099 (−) | 0.909 (+) | 0.385 (−) | 0.176 (−) | 0.368 (−)& | 0.078 (−)& | 0.125 (−)& | |
| DBP | Premenopausal | 0.113 (−) | 0.080 (−) | 0.952 (+) | 0.626 (+) | 0.755 (+) | 0.837 (+) | 0.473 (−) | 0.252 (−) | 0.657 (−) | 0.017 (−) | 0.052 (−) | 0.480 (+) | 0.028 (−) | 0.082 (−) | 0.492 (+) |
| Menopausal | 0.332 (+) | 0.669 (+) | 0.976 (+) | 0.066 (+) | 0.038 (+) | 0.338 (+) | 0.885 (+) | 0.720 (+) | 0.745 (+) | 0.617 (−) | 0.058 (−) | 0.159 (−) | 0.089 (−) | 0.005 (−) | 0.099 (−) | |
| MP effectπ | 0.068 (+) | 0.111 (+) | 0.979 (+) | 0.209 (+) | 0.121 (+) | 0.363 (+) | 0.489 (+) | 0.242 (+) | 0.584 (+) | 0.180 (+) | 0.973 (+) | 0.136 (−) | 0.916 (+)& | 0.295 (−)& | 0.088 (−)& | |
| Glucose | Premenopausal | 0.802 (−) | 0.864 (−) | 0.452 (+) | 0.610 (+) | 0.429 (+) | 0.605 (+) | 0.570 (−) | 0.753 (−) | 0.609 (+) | 0.955 (−) | 0.567 (−) | 0.773 (+) | 0.695 (−) | 0.339 (−) | 0.890 (−) |
| Menopausal | 0.783 (+) | 0.778 (−) | 0.528 (−) | 0.587 (−) | 0.764 (−) | 0.854 (+) | 0.141 (+) | 0.768 (+) | 0.182 (−) | 0.830 (−) | 0.692 (−) | 0.907 (−) | 0.828 (+) | 0.935 (−) | 0.833 (−) | |
| MP effectπ | 0.717 (+) | 0.984 (−) | 0.329 (−) | 0.457 (−) | 0.437 (−) | 0.807 (−) | 0.264 (+) | 0.684 (+) | 0.313 (−) | 0.913 (−) | 0.884 (+) | 0.771 (−) | 0.665 (+)& | 0.524 (+)& | 0.964 (−)& | |
| Insulin | Premenopausal | 0.034 (−) | 0.035 (−) | 0.934 (+) | 0.382 (−) | 0.115 (−) | 0.264 (−) | 0.473 (−) | 0.475 (−) | 0.939 (+) | 0.023 (−) | 0.067 (−) | 0.467 (+) | 0.136 (−) | 0.451 (−) | 0.230 (+) |
| Menopausal | 0.177 (−) | 0.020 (−) | 0.170 (−) | 0.037 (−) | 0.004 (−) | 0.156 (−) | 0.877 (+) | 0.866 (−) | 0.603 (−) | 0.673 (−) | 0.330 (−) | 0.624 (−) | 0.299 (+) | 0.247 (+) | 0.582 (+) | |
| MP effectπ | 0.664 (+) | 0.765 (−) | 0.284 (−) | 0.165 (−) | 0.078 (−) | 0.493 (−) | 0.507 (+) | 0.641 (+) | 0.707 (−) | 0.277 (+) | 0.701 (+) | 0.403 (−) | 0.088 (+)& | 0.168 (+)& | 0.806 (−)& | |
| HOMA-IR | Premenopausal | 0.037 (−) | 0.043 (−) | 0.729 (+) | 0.377 (−) | 0.203 (−) | 0.492 (−) | 0.455 (−) | 0.489 (−) | 0.867 (+) | 0.039 (−) | 0.074 (−) | 0.423 (+) | 0.195 (−) | 0.389 (−) | 0.298 (+) |
| Menopausal | 0.333 (−) | 0.046 (−) | 0.168 (−) | 0.059 (−) | 0.014 (−) | 0.268 (−) | 0.501 (+) | 0.984 (−) | 0.366 (−) | 0.662 (−) | 0.331 (−) | 0.644 (−) | 0.378 (+) | 0.397 (+) | 0.722 (+) | |
| MP effectπ | 0.431 (+) | 0.987 (+) | 0.222 (−) | 0.279 (−) | 0.176 (−) | 0.590 (−) | 0.317 (+) | 0.586 (+) | 0.501 (−) | 0.287 (+) | 0.624 (+) | 0.378 (−) | 0.134 (+)& | 0.230 (+)& | 0.699 (−)& | |
| Total cholesterol | Premenopausal | 0.614 (−) | 0.198 (+) | 0.072 (+) | 0.612 (+) | 0.308 (+) | 0.538 (+) | 0.032 (−) | 0.423 (−) | 0.103 (+) | 0.246 (+) | 0.027 (+) | 0.449 (+) | 0.444 (+) | 0.147 (+) | 0.717 (+) |
| Menopausal | <0.001 (+) | <0.001 (+) | 0.541 (+) | 0.007 (+) | <0.001 (+) | 0.011 (+) | 0.591 (+) | 0.390 (+) | 0.805 (+) | 0.004 (+) | 0.027 (+) | 0.291 (−) | 0.391 (+) | 0.613 (−) | 0.021 (−) | |
| MP effectπ | 0.002 (+) | 0.017 (+) | 0.573 (−) | 0.036 (+) | 0.002 (+) | 0.055 (+) | 0.074 (+) | 0.241 (+) | 0.392 (−) | 0.088 (+) | 0.585 (+) | 0.194 (−) | 0.768 (+)& | 0.221 (−)& | 0.034 (−)& | |
| HDL-cholesterol | Premenopausal | 0.082 (+) | 0.183 (+) | 0.617 (−) | 0.047 (+) | 0.224 (+) | 0.458 (−) | 0.283 (+) | 0.677 (+) | 0.543 (−) | 0.749 (+) | 0.180 (+) | 0.506 (+) | 0.285 (−) | 0.821 (+) | 0.323 (+) |
| Menopausal | 0.153 (+) | 0.014 (+) | 0.253 (+) | 0.203 (+) | 0.064 (+) | 0.474 (+) | 0.594 (−) | 0.934 (+) | 0.392 (+) | 0.195 (+) | 0.054 (+) | 0.613 (+) | 0.997 (−) | 0.980 (+) | 0.874 (−) | |
| MP effectπ | 0.716 (−) | 0.528 (+) | 0.259 (+) | 0.976 (+) | 0.727 (−) | 0.317 (+) | 0.231 (−) | 0.447 (+) | 0.368 (+) | 0.390 (+) | 0.744 (−) | 0.991 (+) | 0.551 (+)& | 0.915 (−)& | 0.491 (−)& | |
| Triglycerides | Premenopausal | 0.413 (−) | 0.400 (−) | 0.779 (+) | 0.365 (−) | 0.764 (−) | 0.509 (+) | 0.128 (−) | 0.236 (−) | 0.796 (+) | 0.216 (+) | 0.817 (+) | 0.728 (−) | 0.126 (+) | 0.713 (+) | 0.495 (−) |
| Menopausal | 0.505 (−) | 0.293 (−) | 0.732 (−) | 0.832 (−) | 0.502 (+) | 0.107 (+) | 0.783 (−) | 0.522 (−) | 0.535 (−) | 0.567 (−) | 0.198 (−) | 0.371 (−) | 0.672 (−) | 0.147 (−) | 0.132 (−) | |
| MP effectπ | 0.993 (−) | 0.772 (−) | 0.658 (−) | 0.655 (+) | 0.484 (+) | 0.444 (+) | 0.274 (+) | 0.544 (+) | 0.571 (−) | 0.279 (−) | 0.214 (−) | 0.535 (−) | 0.246 (−)& | 0.154 (−)& | 0.359 (−)& | |
AEA: N-arachidonoylethanolamide; PEA: N-palmitoylethanolamide; OEA: N-oleoylethanolamide; SBP: systolic blood pressure; DBP: diastolic blood pressure; HOMA-IR: homeostatic model assessment – insulin resistance; HDL: high density lipoprotein.
¥ Effect of BMI on the correlation between NAE values and metabolic parameters within premenopausal and menopausal cohorts. Positive effect (+): the positive (or negative) correlation found within the premenopausal/menopausal cohort increased (or decreased) with increasing BMI classes. Negative effect (−): the positive (or negative) correlation within the premenopausal/menopausal cohort decreased (or increased) with increasing BMI classes. π Effect of MP on the correlation between NAE values and metabolic parameters in all women and within BMI classes. Positive effect (+): the positive (or negative) correlation is higher (or lower) in menopausal women than in premenopausal women. Negative effect (−): the positive (or negative) correlation is lower (or higher) in menopausal women than in premenopausal women. & Interaction between BMI and MP effects on the correlation between NAE values and metabolic parameters. Positive interaction (+): the positive (or negative) effect of BMI on the correlation is higher (or lower) in menopausal than in premenopausal females (i.e.: the positive (or negative) effect of MP on the correlation increased (or decreased) with increasing BMI classes). Negative interaction (−): the positive (or negative) effect of BMI on the correlation is lower (or higher) in menopausal than in premenopausal females (i.e.: the positive (or negative) effect of MP on the correlation decreased (or increased) with increasing BMI classes).