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. 2018 Jul 5;3(4):e00190-18. doi: 10.1128/mSphere.00190-18

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Copyright © 2018 Yadav and Sanyal.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 1 — Dynamic colocalization of MTOCs and the kinetochore during the cell cycle in C. neoformans. (A) Dynamics of colocalization of the kinetochore (mCherry–CENP-A) and MTOCs (Spc98-GFP) at different stages of the cell cycle in C. neoformans. (B) GAL7p-Spc98 conditional mutant was grown in both permissive and repressive media for 12 h. The cells were harvested and studied for the status of kinetochore (marked by GFP–CENP-A) and chromatin (marked by GFP-H4) localization. The cells depleted of Spc98 showed an aberrant kinetochore localization pattern and massive chromosome segregation errors. On the other hand, the cells overexpressing Spc98 behaved in the same fashion as wild-type cells and did not show any difference in kinetochore or chromatin localization. Bars, 5 µm.