Skip to main content
. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Trends Cancer. 2018 Apr 17;4(5):359–373. doi: 10.1016/j.trecan.2018.03.009

Table 1.

Representative T Cell-Targeting PET Probesa

Probe Target Radionuclide Status Application Refs
64Cu-DOTA-ipilimumab CTLA-4 64Cu Preclinical TILs [32]
89Zr-DFO-CD3 CD3 89Zr Preclinical TILs [33]
89Zr-Df-nivolumab PD-1 89Zr Clinical trial TILs [37–39]
89Zr-Df-pembrolizumab PD-1 89Zr Preclinical TILs [41]
89Zr-PEG20-X118-VHH CD8 89Zr Preclinical TILs [57]
89Zr-malDFO-169 CD8 89Zr Preclinical TILs [60]
89Zr-malDFO-GK1.5 cDb CD4 89Zr Preclinical HSCT, IBD [27,61]
89ZrmalDFO-2.43 cDb CD8 89Zr Preclinical HSCT [27]
89Zr-Df-IAB22M2C CD8 89Zr Clinical trial TILs [63]
64Cu-LLP2A VLA4 64Cu Preclinical Tuberculosis [28]
68Ga-NOTA-GZP Granzyme B 68Ga Preclinical TILs [69]
[18F]FB-IL-2 IL-2R 18F Preclinical TILs [75]
[18F]FB-IL-2v IL-2R 18F Preclinical TILs [77]
18F-FLT Thymidine kinase 1 18F Clinical DC vaccine [86]
[18F]FAC dCK 18F Clinical trial Lymphoid organs [88]
[18F]CFA dCK 18F Clinical trial TILs [91,92]
[18F]F-AraG Deoxyguanosine kinase 18F Preclinical GVHD, RA [96,98]
[18F]FHBG HSV1-tk reporter gene 18F Clinical trial CAR-T [109]
89Zr-aTCRmu-F(ab′)2 TCRmu 89Zr Preclinical CAR-T [111,112]
a

Abbreviations: CAR-T, chimeric antigen receptor-expressing T cell; DC, dendritic cell; dCK, deoxycytidine kinase; GVHD, graft-versus-host disease; HSCT, hematopoietic stem cell transplantation; IBD, inflammatory bowel disease; IL-2R, interleukin-2 receptors; RA, rheumatoid arthritis; TCRmu, murine T cell receptor beta domain; TIL, tumor-infiltrating lymphocyte; VLA4, very late antigen-4.