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. Author manuscript; available in PMC: 2019 Apr 4.
Published in final edited form as: Neuron. 2018 Apr 4;98(1):31–48. doi: 10.1016/j.neuron.2018.02.022

Table 3.

Behavior POA stimulation (opto/chemogenetic) POA warming POA cooling POA lesion
Temperature preference Lower (cold-seeking) (Tan et al., 2016) Lower (cold-seeking) (Adair, 1977) Higher (warm-seeking) (Adair, 1977) No effect on LPS-induced cold-seeking (Almeida et al., 2006)
Operant responses for heat reward ND Decrease in cold (Carlisle, 1966; Laudenslager, 1976) Increase at baseline (Satinoff, 1964) and in cold (Laudenslager, 1976) Increase in cold (Carlisle, 1969; Schulze et al., 1981)
Operant responses for cool reward ND Increase at baseline (Cabanac and Dib, 1983) No effect at baseline (Cabanac and Dib, 1983) Increase in heat (Lipton, 1968)
Postural extension Increased at baseline (Yu et al., 2016) Increased at baseline (Roberts and Mooney, 1974) ND Reduced in heat (Roberts and Martin, 1977; Whyte et al., 2006)

References

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Almeida, M.C., Steiner, A.A., Branco, L.G., and Romanovsky, A.A. (2006). Cold-seeking behavior as a thermoregulatory strategy in systemic inflammation. Eur J Neurosci 23, 3359-3367.

Cabanac, M., and Dib, B. (1983). Behavioural responses to hypothalamic cooling and heating in the rat. Brain Res 264, 79-87.

Carlisle, H.J. (1966). Behavioural significance of hypothalamic temperature-sensitive cells. Nature 209, 1324-1325.

Carlisle, H.J. (1969). Effect of preoptic and anterior hypothalamic lesions on behavioral thermoregulation in the cold. J Comp Physiol Psychol 69, 391-402.

Laudenslager, M.L. (1976). Proportional hypothalamic control of behavioral thermoregulation in the squirrel monkey. Physiol Behav 17, 383-390.

Lipton, J.M. (1968). Effects of preoptic lesions on heat-escape responding and colonic temperature in the rat. Physiol Behav 3, 165-169.

Roberts, W.W., and Martin, J.R. (1977). Effects of lesions in central thermosensitive areas on thermoregulatory responses in rat. Physiol Behav 19, 503-511.

Roberts, W.W., and Mooney, R.D. (1974). Brain areas controlling thermoregulatory grooming, prone extension, locomotion, and tail vasodilation in rats. J Comp Physiol Psychol 86, 470-480.

Satinoff, E. (1964). Behavioral Thermoregulation in Response to Local Cooling of the Rat Brain. Am J Physiol 206, 1389-1394.

Schulze, G., Tetzner, M., and Topolinski, H. (1981). Operant thermoregulation of rats with anterior hypothalamic lesions. Naunyn Schmiedebergs Arch Pharmacol 318, 43-48.

Tan, C.L., Cooke, E.K., Leib, D.E., Lin, Y.C., Daly, G.E., Zimmerman, C.A., and Knight, Z.A. (2016). Warm-Sensitive Neurons that Control Body Temperature. Cell 167, 47-59 e15.

Whyte, D.G., Brennan, T.J., and Johnson, A.K. (2006). Thermoregulatory behavior is disrupted in rats with lesions of the anteroventral third ventricular area (AV3V). Physiol Behav 87, 493-499.

Yu, S., Qualls-Creekmore, E., Rezai-Zadeh, K., Jiang, Y., Berthoud, H.R., Morrison, C.D., Derbenev, A.V., Zsombok, A., and Munzberg, H. (2016). Glutamatergic Preoptic Area Neurons That Express Leptin Receptors Drive Temperature-Dependent Body Weight Homeostasis. J Neurosci 36, 5034-5046.