Table 4.
Children’s Hospital of Philadelphia versus Children’s Hospital Los Angeles Cohort Demographics, Comorbidities, Ventilator Management, and Outcomes among All Patients with Acute Respiratory Distress Syndrome
| CHLA (N = 612) | CHOP (N = 453) | P Value | |
|---|---|---|---|
| Age, mo | 46 (11.2 to 141) | 49 (16.8 to 143) | 0.16 |
| ARDS trigger | |||
| Pneumonia | 361 (59) | 299 (66) | 0.02 |
| Sepsis | 225 (36.8) | 98 (21.6) | <0.001 |
| Neurological disease | 165 (27) | 95 (21) | 0.02 |
| Trauma | 43 (7) | 29 (6.4) | 0.7 |
| Drowning | 9 (1.5) | 11 (2.4) | 0.255 |
| Aspiration | 28 (4.6) | 54 (11.9) | <0.001 |
| Comorbidities | |||
| Immunodeficiency | 161 (26.3) | 87 (19) | 0.007 |
| Stem cell transplant | 31 (5) | 33 (7.3) | 0.13 |
| Cancer | 100 (16.3) | 61 (13.4) | 0.19 |
| Solid transplant | 35 (5.7) | 6 (1.3) | <0.001 |
| PRISM III raw score | 11 (6 to 17) | 11 (5 to 17) | 0.47 |
| Day 1 ventilator settings | |||
| FiO2 | 0.49 (0.41 to 0.65) | 0.45 (0.37 to 0.56) | <0.0001 |
| Mean airway pressure, cm H2O | 13.3 (10.2 to 17.7) | 16 (14 to 19) | <0.0001 |
| PEEP, cm H2O | 8.0 (6 to 10) | 10 (8 to 11.4) | <0.0001 |
| PF ratio | 190 (128 to 258) | 210 (162 to 251) | 0.01 |
| OI | 6.6 (4.4 to 11.8) | 8.4 (6.2 to 13.5) | <0.0001 |
| Driving pressure, cm H2O | 19.5 (16 to 22.5) | 19.5 (16 to 23.5) | 0.18 |
| Vt, ml/kg | 7.6 (6.2 to 9.1) | 7.4 (6.6 to 8.2) | 0.06 |
| PEEP discordance | 0 (−2 to 0) | 2 (0 to 3) | <0.0001 |
| Low | 222 (40.2) | 53 (12.4) | <0.0001 |
| On | 196 (35.3) | 123 (28.8) | |
| High | 134 (24.3) | 251 (58.8) | |
| Inotropes or vasopressors | 270 (44.1) | 360 (79) | <0.0001 |
| Nitric oxide | 62 (10.1) | 161 (35) | <0.0001 |
| Outcomes | |||
| Mortality | 137 (22.4) | 65 (14.4) | 0.001 |
| 28-day VFDs | 16.7 (0 to 23) | 16 (3 to 21) | 0.01 |
Definition of abbreviations: ARDS = acute respiratory distress syndrome; CHLA = Children’s Hospital Los Angeles; CHOP = Children’s Hospital of Philadelphia; IQR = interquartile range; OI = oxygenation index; PEEP = positive end-expiratory pressure; PF = PaO2/FiO2; PRISM = Pediatric Risk of Mortality; VFD = ventilator-free days.
Data are presented as median (IQR) and n (%). See online supplement for subgroups by PF ratio.