Table 1.

AICAR, but not metformin, mitigates muscle atrophy in the C26 murine model of cancer cachexia

	Saline	C26	C26 + AICAR	C26 + Metformin
Body Weight Change (%)	5.0 ± 0.4	−19.0 ± 1.7**	−9.6 ± 2.5** , ††	−16.3 ± 1.5**
Tibialis Anterior (mg)	37.6 ± 2.2	26 ± 1.5 **	31.3 ± 1.4 * , †	25.4 ± 0.7 **
Gastrocnemius (mg)	122.6 ± 2.1	87.3 ± 3.9**	101.8 ± 2.7** , †	83.8 ± 4.6**
Fat Pad (mg)	137 ± 6.9	10.9 ± 6.4**	15 ± 6.6**	11.8 ± 3.1**
Tumor (g)	NA	1.024 ± 0.060	1.038 ± 0.104	1.007 ± 0.065
n	9	10	6	8
IL‐6 (pg/ml) (n = 4)	30.8 ± 1.7	253.9 ± 46.1**	201.9 ± 55.2*	127.7 ± 34.9†

Values represent the mean ± SEM.

*P < 0.05, **P < 0.01 compared to Saline cohort.

^† P < 0.05, ^†† P < 0.01 compared to C26 cohort.