Table 2.

AICAR, but not metformin, mitigates muscle atrophy in the LPS model of septic cachexia

	Vehicle	PF	LPS	LPS + AICAR	LPS + Metformin
Body Weight Change (%)	2.1 ± 0.2**	−9.5 ± 1.3	−10.4 ± 0.7	−6.5 ± 1*	−11.4 ± 0.4
Tibialis Anterior (mg)	44.1 ± 3.4	43.2 ± 0.8	38.3 ± 1.5**	42.2 ± 0.9	39.2 ± 1.2*
Gastrocnemius (mg)	156.5 ± 4.8	145.7 ± 3.2	136.3 ± 3.6*	144.8 ± 2.9	136.5 ± 2.2*
Fat Pad (mg)	99.7 ± 10.6	97.6 ± 10.3	106.1 ± 16.8	95.5 ± 8.1	107.7 ± 12.1
n	4	11	11	11	11

Values represent the mean ± SEM.

*P < 0.05, **P < 0.01 compared to the pair‐fed (PF) cohort.