Figure 6. Fibrinogen elimination of B220⁺CD11c⁺NK1.1⁺HepELs via FX in pre‐metastatic lungs.

• A
  Representative immunostaining of fibrinogen depositions in tumour‐bearing mouse lungs received an injection of rhodamine‐labelled B220⁺CD11c⁺NK1.1⁺HepELs derived from tumour‐bearing‐ FX^+/− or FX^−/− mice (scale bar, 20 μm).
• B
  Immunohistochemical quantifications of fibrinogen depositions in tumour‐bearing mouse lung after an injection of B220⁺CD11c⁺NK1.1⁺ cells derived from tumour‐bearing‐ FX^+/− or FX^−/− mouse liver. Sorted B220⁺CD11c⁺NK1.1⁺ cells were prepared from three mice per each genotype and were i.v. injected. Shown are averages (N = 6/group, 4 sections/mouse) with SEM and Welch's t‐test.