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. 2018 Jul 7;24(25):2764–2775. doi: 10.3748/wjg.v24.i25.2764

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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Difference of the risk of Mycobacterium tuberculosis infection between patients with Crohn’s disease treated with tumor necrosis factor-alpha inhibitors and those treated with placebo. Risk difference was calculated after arcsine transformation of Mycobacterium tuberculosis incidence (Arcus sinus difference, ASD) and indicated by the numbers on x-axis. Weight: the percentage contribution of an individual study to the overall estimation. The x-axis indicates the risk difference. The vertical dashed line indicates the overall point estimate. The solid horizontal lines show the confidence interval (CI). The size of the black box and diamond is proportional to the corresponding weight.