Table 3.
Estimated absolute incidence of Mycobacterium tuberculosis infection in patients with Crohn’s disease treated with tumor necrosis factor-alpha inhibitors and the number of patients with Crohn’s disease who need to be treated with tumor necrosis factor-alpha inhibitors to expect one Mycobacterium tuberculosis case
| Incidence of TB with TNFα treatment (cases/person-years)1 | Number of patients treated to see one TB Case in one year | |
| Based on risk difference | 177/100000 | 565 |
| Based on relative odds estimated with background correction | 97/100000 | 1031 |
| Based on relative odds estimated without background correction | 117/100000 | 855 |
1
The background incidence was assumed to be 20 cases/100000 person-years as reported by Aberra et al[24]. TB: Mycobacterium tuberculosis.