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. 2018 Jul 7;24(25):2733–2740. doi: 10.3748/wjg.v24.i25.2733

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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Transforming growth factor-β can promote the proliferation of tumor cells and increase the level of interleukin-6 in hepatocellular carcinoma cell lines production. A: The cell numbers of the three HCC cell lines after treatment with 100 ng/mL rhTGF-β for 48 h; B: The three HCC culture supernatants were analyzed for protein levels of IL-6 after treatment with rhTGF-β for 48 h using ELISA; C: The three HCC cell lines were treated with or without rhIL-6 for 48 h, and cell proliferation was determined by MTT assay. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. TGF-β: Transforming growth factor-β; Treg: Regulatory cells; HCC: Hepatocellular carcinoma.