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Schematic structure of BRCA1-associated protein-1 (BAP1) domains and locations of reported germline mutations. Consists of: ubiquitin carboxyl hydrolase (UCH) domain; HBM, host cell factor 1 (HCF1) binding domain; nuclear localization signals (NLS); C-terminal domain (CTD), additional sex combs like (ASXL1/2) binding domain; BRCA1-associated RING domain protein 1 (BARD1) binding region; Breast Cancer type 1 (BRCA1) binding region and Ying Yang 1 (YY1) binding region.
