Table 3.
Protein deposition and neurodegenerative diseases
| Disease | Protein | Aggregate |
|---|---|---|
| Prion disease | PrPSc | PrP amyloid |
| Alzheimer ásease | Aß | Aß amyloid |
| tau | PHF in MFT | |
| FTD | tau | straight filaments PHF |
| Pick's disease | tau | Pick bodies |
| Parkinson's disease | ą synuclein | Levy bodies |
| PSP | tau | straight filaments PHF |
| ALS(MND) | neurofilament | neuronal aggregates |
| HD | Huntingdon | nuclear inclusions |
| Spinocerebellar ataxias 1 | ataxin 1 | nuclear inclusions |
| Spinocerebellar ataxias 2 | ataxin 2 | cytoplasmic inclusions |
| Macado-Joseph disease | ataxin 3 | nuclear inclusions |
NFT=neurofibrillary tangles; PHF=paired helical filaments