Table 1.

SNPs associated with serum urate levels and habitual coffee intake in previous GWAS using participants of European ancestry

		GCKR	ABCG2	MLXIPL	CYP1A2
Coffee GWAS [20]	SNP	rs1260326	rs1481012	rs7800944	rs2472297
	Chr: Position (B37)	2:27730940	4:89039082	7:73035857	15:75027880
	Effect allele/other	T/C	A/G	T/C	T/C
	Effect allele freq.	0.41	0.89	0.72	0.24
	Beta (cups/day)	−0.04	0.06	−0.05	0.15
	SE	0.01	0.01	0.01	0.01
	P	1.06 × 10−7	1.13 × 10−6	7.82 × 10−9	6.45 × 10−47
Urate GWAS [2]	SNP	rs1260326	rs2231142	rs1178977	rs2472297
	Chr: Position (B37)	2:27730940	4:89271347	7:72494985	15:75027880
	Effect allele/other	T/C	G/T	A/G	T/C
	Effect allele freq.	0.41	0.89	0.81	0.24
	Beta (mg/dl)	0.07	−0.22	0.05	−0.03
	SE	0.01	0.01	0.01	0.01
	P	1.20 × 10−44	1.00 × 10−134	1.20 × 10−12	3.85 × 10−6
LD	Euro r2	Same SNP	0.94	0.58	Same SNP
			rs2231142: T	rs1178977: G
			rs1481012: G	rs7800944: C
	UKBB r2	Same SNP	0.99	0.57	Same SNP
			rs2231142: T	rs1178977: G
			rs1481012: G	rs7800944: C

Linkage disequilibrium calculated using 1000 Genomes phase 3 (September 2014) data

Chr chromosome, Euro European from 1000 Genomes, Freq frequency, GWAS genome-wise association study, LD linkage disequilibrium, SE standard error, SNP single nucleotide polymorphism, UKBB UK Biobank