Table 4.
Association analysis of urate-associated SNPs with gout and coffee intake
| Association of gout with urate-associated SNPs | Association of coffee intake (cups per day) with urate-associated SNPs | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | SNP | Effect allele | Observations | % | Odds ratio | 95% Confidence interval | P | Observations | % | Unadjusted β coefficient | 95% Confidence interval |
P |
| GCKR | ||||||||||||
| Unadjusted | rs1260326 | T | 130,966 | 100.0% | 1.40 | 1.27–1.53 | 3.34 × 10−12 | 130,731 | 100.0% | −0.07 | −0.10 to −0.05 | 1.33 × 10−8 |
| Adjusted† | 121,940 | 93.1% | 1.43 | 1.29–1.58 | 4.05 × 10−12 | 121,897 | 93.2% | −0.08 | −0.10 to −0.05 | 3.05 × 10−10 | ||
| Adjusted† including beer/spirits | 86,702 | 66.2% | 1.45 | 1.30–1.62 | 2.32 × 10−11 | 86,676 | 66.3% | −0.07 | −0.10 to −0.05 | 2.47 × 10−8 | ||
| ABCG2 | ||||||||||||
| Unadjusted | rs2231142 | T | 130,966 | 100.0% | 2.26 | 2.07–2.47 | 1.05 × 10−72 | 130,731 | 100.0% | −0.07 | −0.10 to −0.04 | 1.00 × 10−6 |
| Adjusted† | 121,940 | 93.1% | 2.37 | 2.15–2.61 | 6.62 × 10−69 | 121,897 | 93.2% | −0.09 | −0.11 to −0.06 | 2.10 × 10−9 | ||
| Adjusted† including beer/spirits | 86,702 | 66.2% | 2.45 | 2.20–2.72 | 4.78 × 10−61 | 86,676 | 66.3% | −0.08 | −0.11 to −0.05 | 3.99 × 10−7 | ||
| MLXIPL | ||||||||||||
| Unadjusted | rs1178977 | A | 130,966 | 100.0% | 1.25 | 0.98–1.61 | 0.07 | 130,702 | 100.0% | −0.15 | −0.21 to −0.09 | 3.00 × 10−6 |
| Adjusted† | 121,940 | 93.1% | 1.24 | 0.95–1.61 | 0.11 | 121,897 | 93.2% | −0.17 | −0.23 to −0.11 | 3.20 × 10−8 | ||
| Adjusted† including beer/spirits | 86,702 | 66.2% | 1.24 | 0.94–1.65 | 0.13 | 86,661 | 66.3% | −0.21 | −0.27 to −0.14 | 5.45 × 10−10 | ||
| CYP1A2 | ||||||||||||
| Unadjusted | rs2472297 | C | 130,966 | 100.0% | 1.15 | 0.96–1.37 | 0.13 | 130,731 | 100.0% | −0.25 | −0.30 to −0.21 | 3.02 × 10−26 |
| Adjusted† | 121,940 | 93.1% | 1.16 | 0.96–1.40 | 0.12 | 121,897 | 93.2% | −0.30 | −0.35 to −0.26 | 7.61 × 10−40 | ||
| Adjusted† including beer/spirits | 86,702 | 66.2% | 1.16 | 0.94–1.42 | 0.17 | 86,676 | 66.3% | −0.30 | −0.35 to −0.25 | 2.80 × 10−32 | ||
Analysis is shown for the presence of at least one urate-raising allele
Effect allele is allele associated with hyperuricaemia in Kottgen GWAS paper [2]
SNP single nucleotide polymorphism
†Adjusted for age, sex, body mass index, hypertension, kidney disease, diabetes, meat intake, fish intake, cheese intake, tea intake, fruit intake, vegetable intake, bread intake, and cereal intake