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. 2018 Jul 5;18:714. doi: 10.1186/s12885-018-4630-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Effect of 3AOA on tumor-induced lymphangiogenesis in a VEGF-A-induced oral cancer sentinel lymph node animal model. a, Lymphatic vessel density values in tumor and SLN sections were measured by immunohistochemical analysis using anti-LYVE-1 antibody. All sections were digitalized and images were captured under 200× objective magnification. Scale bar = 200 μm. b-c, Immunohistochemical intensity values of LYVE-1 from captured images of tumors and SLN were analyzed via the Image J program and represented as a bar diagram. Data are presented as a mean ± S.D. (^*p < 0.05, ^***p < 0.001). T = tumor; SLN = Sentinel lymph node