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. 2018 Jul 5;10:92. doi: 10.1186/s13148-018-0523-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Identification of methylation-dependent SOX genes associated with prognosis in AML. a The prognostic value of SOX gene methylation for OS and LFS among CN-AML patients from TCGA databases. SOX gene methylation (HM450) data was downloaded via cBioPortal (http://www.cbioportal.org). AML patients were divided into two groups by the median methylation level of each gene respectively. b Correlation between SOX genes expression and methylation among AML patients from TCGA databases. SOX gene methylation (HM450) and mRNA expression (RNA Seq V2 RSEM) data was downloaded via cBioPortal (http://www.cbioportal.org). The correlation analysis was conducted by Spearman test. c SOX30 methylation level in AML patients and controls obtained by bioinformatics analysis. SOX30 promoter (CpG island) methylation level was obtained through the human disease methylation database DiseaseMeth version 2.0 (http://www.bio-bigdata.com/diseasemeth/analyze.html). d The prognostic value of SOX30 expression for OS among CN-AML patients obtained by bioinformatics analysis. The effect of SOX30 expression on prognosis was determined by the Genomicscape Survival Analysis (http://genomicscape.com/microarray/survival.php)