Table 1.

Basic Science Morris Glossary

Term	Translation	Implication
Transient analysis	Calculations based on full cardiac cycle data computations	More points to compute
Pseudo-transient analysis	Calculation based on mean of cardiac cycle data	Fewer points to compute
Sobol decomposition, sensitivity analysis index values, variance-based model	Breakdown of factors and their relative contribution to model variance	Potentially allows elimination of unimportant variables and shows most impactful variables
vFFR steady	Computed during constant pressure	Less computing time
vFFR tms	Computed during transient pressure cycle	More computing time
vFFR ps-tms	Computed during pseudo-transient pressure cycle	Less computing time
z1, z2	Coefficients of pressure drop	Components of CMVR, lesion specific
Plug velocity profile	Term related to shape of flow velocity profile within a vessel	Blunt flow profile versus bullet-shaped laminar flow profile may influence results
Uniform zero pressure outlet	Setting of boundary conditions to presumed zero pressure outside of the system studied	Simplified assumption, but risks not accounting for venous pressure or collaterals. Neglects changes in pressure and flow by wave reflection from downstream vessels. Uncertain impact on vFFR
Windkessel parameters	Physiologic model describing the heart and arterial system as a closed hydraulic circuit. Parameters include arterial compliance, resistance, and inertia.	Basis for any model of pressure and flow in the coronary arteries

CMVR = coronary microvascular resistance; vFFR = virtual fractional flow reserve; ps-tms = computed with pseudo-transient steady-state method; tms = calculated with full transient computational fluid dynamics.