Figure 2.

Intact ECM Scaffold Attenuates Maladaptive Structural Remodeling

(A) Representative images of LV divided long axis depicting relative LV volumes and geometry. (B) Representative images of the treated infarcted anterior LV wall (dashed line indicates the endocardial and epicardial borders of the LV wall) depicting anterior wall thickness and ECM scaffold. (C) LVEDV measured by PV loop analysis in sham-treated (n = 16) and intact (n = 16) and glutaraldehyde-inactivated (n = 16) ECM scaffold–treated animals 14 weeks post-MI (1-way ANOVA). Infarcted LV anterior wall thickness measured by echocardiography in sham-treated (n = 16) and intact (n = 16) and glutaraldehyde-inactivated (n = 16) ECM scaffold–treated animals. (D) Significant differences were observed for effects of time (p = 0.0012), group (p = 0.034), and interaction (group × time, p = 0.034) (repeated measures 2-way ANOVA). (E) LV stiffness indicated by end-diastolic pressure-volume relationship (EDPVR) measured by PV loop analysis in sham-treated (n = 16) and intact- (n = 16) and glutaraldehyde-inactivated (n = 16) ECM scaffold–treated animals 14 weeks post-MI (1-way ANOVA). Abbreviations as in Figure 1.