Figure 5.

Provasculogenic Paracrine Response to Intact ECM Scaffold

Fold change relative to control in FGF-2 (A), VEGF (B), and HGF (C) concentrations measured by multiplex assays of the conditioned media of human cardiac fibroblasts grown on plastic (n = 6), intact ECM scaffold (n = 6), or glutaraldehyde-inactivated ECM scaffold (n = 6; Student t test). FGF-2 (D), VEGF (E), and HGF (F) concentrations measured by multiplex assays of the conditioned media of human cardiac fibroblasts grown on plastic (n = 3), intact ECM scaffold (n = 3), or intact ECM scaffold in the presence of 1 μmol/l of FGF-2 receptor inhibitor PD 173074 (n = 3; Student t test). Abbreviations as in Figures 1, 3, and 4.