Table 2.
Effect of 2-Day Gevokizumab Treatment in Goto-Kakisaki Rats
| Ischemia/Reperfusion |
||
|---|---|---|
| Untreated | Gevokizumab Treated | |
| LV weight, g | 0.90 ± 0.02 | 0.86 ± 0.01 |
| Area at risk, % of LV | 43.4 ± 3.0 | 45.2 ± 4.9 |
| Infarct size, % of LV | 16.6 ± 1.8 | 7.6 ± 1.9∗ |
| LV ESP, mm Hg | 93.9 ± 6.8 | 90.0 ± 5.2 |
| LV ESPVR, mm Hg/RVU | 12.5 ± 1.0 | 16.4 ± 1.0∗ |
| LV EDP, mm Hg | 2.06 ± 0.31 | 1.27 ± 0.15∗ |
| LV EDPVR, mm Hg/RVU | 2.15 ± 0.21 | 1.44 ± 0.17∗ |
Values are mean ± SD.
Abbreviations as in Table 1.
p <0.05 versus untreated I/R. n = 10 to 15 per group.