Figure 5.

Correlation between targeting to tumor and suppression effect of tumor growth. (A) Comparative imaging of a single-dose and multifractionated doses of irradiation in mice with before (Pre) and after 6 hours (6 h) of administration of PSP1-flamma675. (B-C) Correlation between fluorescence intensities and tumor volumes from the first and second round of imaging in mouse of 2 Gy × 5 radiation. The result was with tumor volumes (correlation coefficient r² = 0.848) compared to those of tumor at 1 week (r² = 0.534). (D) Changes in tumor volume in mouse with no radiation (0G: ◆) and 5 times 2 Gy radiation (2G*5: ■). The optical imaging was performed at 8 days (1 round imaging) and 23 days (2 round imaging) after the initiation of irradiation as shown in A. (E) Ex vivo fluorescence images of major organs and tumors from PSP1-treated mouse after excision at 24 hours postinjection of PSP1.