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Drug Interactions Between Immunosuppressants and Direct-Acting Antiviral Regimens
| Regimens | Common Immunosuppressant Medications | ||||
|---|---|---|---|---|---|
| Prednisone | Tacrolimus | Mycophenolate Mofetil | Cyclosporine | Sirolimus | |
| Ledipasvir/sofosbuvir | – | – | – | – | – |
| Glecaprevir/pibrentasvir | – | – | – | +a | – |
| Sofosbuvir/daclatasvir plus ribavirin | – | – | – | – | – |
Cyclosporine dosages of 100 mg or more increase the concentration of glecaprevir/pibrentasvir and may increase side effects.35
