. Author manuscript; available in PMC: 2018 Jul 6.

Published in final edited form as: J Clin Lipidol. 2018 Mar 2;12(3):718–727.e6. doi: 10.1016/j.jacl.2018.02.010

Table S5. The Omega-3 Index vs the n-6:n-3 ratio and vs the Omega-3 Index adjusting for all n-6 fatty acids (n = 2500).

	Hazard ratios (95% CIs)
	Total CVD	Total CHD	Total stroke	CVD mortality	Cancer mortality	Other mortality	Any Mortality
Omega-3 Index ^§
<4.2%	1.0	1.0	1.0	1.0	1.0	1.0	1.0
4.2%–4.9%	1.06 (0.69, 1.63)	1.05 (0.60, 1.83)	1.16 (0.60, 2.24)	0.57 (0.23, 1.40)	0.66 (0.38, 1.14)	*0.54 (0.31, 0.94)* ^*	0.74 (0.53, 1.04)
4.9%–5.7%	1.10 (0.72, 1.68)	0.81 (0.44, 1.48)	1.30 (0.68, 2.49)	0.54 (0.20, 1.47)	0.73 (0.42, 1.28)	*0.38 (0.20, 0.73)* ^†	*0.67 (0.46, 0.96)* ^*
5.7%–6.8%	0.74 (0.47, 1.17)	0.63 (0.34, 1.20)	0.59 (0.28, 1.25)	0.56 (0.22, 1.43)	0.60 (0.35, 1.03)	*0.44 (0.25, 0.79)* ^†	*0.59 (0.41, 0.86)* ^†
>6.8%	*0.61 (0.37, 0.99)* ^*	0.58 (0.29, 1.18)	0.45 (0.20, 1.03)	0.39 (0.15, 1.02)	0.96 (0.56, 1.64)	*0.44 (0.24, 0.79)* ^†	*0.66 (0.45, 0.96)* ^*
P-value for trend	*.008* ^†	*.03* ^*	*.006* ^†	.10	.88	*.009* ^†	*.02* ^*
n6:n3 ratio^§
<3.31	1.0	1.0	1.0	1.0	1.0	1.0	1.0
3.32–3.99	1.11 (0.70, 1.78)	0.93 (0.33, 1.96)	1.34 (0.56, 3.19)	1.17 (0.45, 3.02)	0.65 (0.37, 1.15)	1.20 (0.66, 2.20)	0.98 (0.67, 1.41)
3.99–4.56	*1.69 (1.10, 2.62)* ^*	1.26 (0.65, 2.46)	*3.08 (1.45, 6.54)* ^†	1.41 (0.58, 3.46)	0.83 (0.48, 1.42)	0.83 (0.43, 1.59)	1.00 (0.69, 1.45)
4.56–5.20	*1.64 (1.06, 2.53)* ^*	1.62 (0.86, 3.06)	*2.52 (1.15, 5.54)* ^*	1.12 (0.45, 2.75)	0.75 (0.42, 1.35)	1.12 (0.62, 2.00)	1.11 (0.78, 1.59)
>5.20	1.61 (0.99, 2.62)	1.88 (0.95, 3.74)	2.02 (0.88, 4.65)	2.46 (0.93, 6.51)	1.12 (0.65, 1.93)	*2.43 (1.36, 4.35)* ^†	*1.58 (1.08, 2.31)* ^*
P-value for trend	*.008* ^†	*.014* ^*	*.012* ^*	.14	.68	*.023* ^†	*.019^
Omega-3 Index + all n-6 fatty acids^§
<4.2%	1.0	1.0	1.0	1.0	1.0	1.0	1.0
4.2%–4.9%	1.03 (0.67, 1.57)	1.04 (0.59, 1.83)	1.15 (0.59, 2.24)	0.52 (0.20, 1.38)	0.66 (0.38, 1.14)	0.43 (0.23, 0.78)	0.67 (0.47, 0.95)^*
4.9%–5.7%	1.04 (0.67, 1.62)	0.85 (0.45, 1.58)	1.22 (0.60, 2.47)	0.46 (0.16, 1.35)	0.72 (0.39, 1.32)	*0.32 (0.17, 0.62)* ^‡	*0.63 (0.43, 0.92)* ^*
5.7%–6.8%	0.65 (0.40, 1.08)	0.65 (0.32, 1.34)	0.50 (0.22, 1.15)	0.52 (0.18, 1.46)	0.55 (0.28, 1.10)	*0.33 (0.16, 0.68)* ^†	*0.52 (0.34, 0.80)* ^†
>6.8%	*0.48 (0.26, 0.91)* ^*	0.62 (0.26, 1.44)	0.33 (0.10, 1.04)	0.37 (0.10, 1.31)	0.92 (0.41, 2.10)	*0.32 (0.13, 0.78)* ^*	0.61 (0.36, 1.04)
P-value from trend	*.014*	.14	*.02* ^*	.16	.58	*.006* ^†	*.025* ^*

CVD, cardiovascular disease; CHD, coronary heart disease; CI, confidence interval.

P < .05

^†

P < .01

^‡

P < .001.

All significant hazard ratios/P-values are shown in bold italics.

^§

Adjusted for all variables in Table 1 except baseline CVD.