Table 1.
Total social interaction (including aggressive grooming, seconds), pinning (frequency), pouncing (frequency), and cage crossings (frequency) during a 15 min social encounter with a novel same-sex rat. Experimental animals were either socially reared (SR) or had experienced 4 weeks of post-weaning social isolation (PSI) and acute treatment with vehicle (0 mg/kg) or MJN110. Values are means and SEMs of 8 rats/group.
| 0 mg/kg | 1 mg/kg | 5 mg/kg | ||||
|---|---|---|---|---|---|---|
| Total Social Interaction a, b | SR | PSI | SR | PSI | SR | PSI |
| Female | 531 (42.8) | 687 (31.4) | 581 (30.7) | 625 (49.1) | 503 (33.8) | 718 (24.8) |
| Male | 343 (96.2) | 465 (48.7) | 333 (31.9) | 353 (47.9) | 231 (31.8) | 380 (25.9) |
| Pinning a, b, c | ||||||
| Female | 5.87 (1.2) | 5.57 (1.6) | 6.55 (1.4) | 4.33 (0.9) | 4.28 (0.9) | 5.0 (1.5) |
| Male | 4.87 (1.5) | 13.37 (2.7) | 5.22 (1.9) | 9.25 (2.3) | 3.63 (1.5) | 11.38 (2.4) |
| Pouncing a, b | ||||||
| Female | 24.0 (3.3) | 36.3 (4.0) | 21.8 (3.2) | 34.7 (4.2) | 19.4 (3.0) | 34.3 (3.5) |
| Male | 10.8 (2.2) | 22.3 (3.8) | 12.7 (1.5) | 16.6 (1.0) | 10.9 (1.9) | 23.8 (3.4) |
| Cage crossings a, b, d | ||||||
| Female | 60.5 (4.97) | 77.4 (9.14) | 51.5 (3.38) | 73.1 (5.7) | 46.6 (4.0) | 82.5 (2.24) |
| Male | 41.7 (3.2) | 52.0 (3.6) | 43.1 (4.3) | 52.5 (6.2) | 33.8 (4.1) | 60.2(6.5) |
a
, main effect of Rearing, p < 0.01;
b
, main effect of Sex, p < 0.01;
c
, Rearing by Sex interaction, p < 0.01;
d
, Rearing by Dose interaction, p < .05.