Skip to main content
. Author manuscript; available in PMC: 2018 Jul 6.
Published in final edited form as: ChemMedChem. 2017 May 22;12(11):845–849. doi: 10.1002/cmdc.201700182

Table 2.

Inhibitory activity against VIM2

Compound N Ki (μM) IC50 (μM) LE
L-Captopril 14 0.63 6.6 (4.4) 0.61
2b 8 0.217 0.908 1.15
3 11 0.013 0.27 0.99
5 21 7.5 67.9 0.34

Ligand efficiency (LE) = -1.38 log (Ki) / N where N = number of heavy atoms.

IC50 in parenthesis reported from ref. 3.