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Cell bioactivities and plasma stability
| Compound | CC50 (μM) | EC50* (μM) | TI | Human Plasma t1/2 (mins) | Mouse Plasma t1/2 (mins) |
|---|---|---|---|---|---|
| L-Captopril | - | 1.7 | - | - | - |
| 2b | 0.014 | - | - | - | - |
| 3 | 97 | 0.110 | 880 | 11.7 | 12.7 |
t1/2 – Half-life.
EC50* was determined in the presence of 50 μM amoxicillin.
Therapeutic index (TI) = CC50/50.
