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. Author manuscript; available in PMC: 2019 Apr 15.
Published in final edited form as: Neuroscience. 2017 Dec 30;376:40–47. doi: 10.1016/j.neuroscience.2017.12.021

Figure 5. Effects of MMP-9 deficiency on fibrin(ogen) deposition in the brain after stroke.

Figure 5

(A, B) Merged immunofluorescence images of fibrin(ogen) deposition (red, arrows), type IV collagen (green, blood vessels) or both (yellow) in the ischemic (A) vs non-ischemic hemisphere (B) of MMP-9+/+ mice with increased α2-antiplasmin. Blue color represents DAPI stained nuclei. (C, D) Representative (100 μm) images showing fibrinogen deposition in the ischemic (C) vs non-ischemic hemisphere (D) in MMP-9−/− mice with increased α2-antiplasmin. (E) Average area of fibrin(ogen) deposition in the ischemic (IH) vs the non- ischemic (NIH) hemisphere in 8-10 images from each hemisphere in MMP-9+/+ and MMP-9−/− mice. N=4-6, **p<0.01, *p<0.05, ns- non significant.