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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Alcohol Clin Exp Res. 2018 Apr 18;42(5):879–888. doi: 10.1111/acer.13626

Figure 4. Bi-directional modulation of NAc core activity and chronic binge-like ethanol drinking.

Figure 4

a) Ethanol intake presented as average individual difference scores (intake during treatment with CNO – intake during treatment with vehicle) suggests bidirectional modulation of binge-like drinking in the mice treated with hM3Dq as compared with hM4Di (One way ANOVA, F(2,33)=3.6, p<0.05). Bonferroni post-hoc *=p<0.05. b) Two-way ANOVA identified a significant group × treatment interaction (F(2,33)=3.57, * p<0.05), with a Bonferroni post-hoc test revealing significant differences between hM3Dq and hM4Di groups in response to CNO treatment (* p<0.05). c) Diagram (left; from Franklin and Paxinos, 2007) and 4× image (right) of coronal section showing targeting of NAc core (where green indicates viral transduction and blue indicates DAPI stain). n=11–13/group.