Table III.
Group | LVEDV (µl) | LVEDD (mm) | LVESV (µl) | LVESD (mm) |
---|---|---|---|---|
Sham | 226.22±48.92 | 5.68±0.54 | 81.21±15.12 | 3.25±0.33 |
IR | 738.17±92.36a | 11.37±2.10a | 266.40±11.22a | 7.83±1.00a |
NC | 739.10±89.25a | 11.40±2.00a | 267.40±11.12a | 7.84±1.10a |
miR-20b-5p mimics | 939.25±111.32a,b,c | 31.40±2.00a,b,c | 366.40±11.22a,b,c | 10.83±1.00a,b,c |
miR-20b-5p inhibitors | 414.79±89.25a,b,c | 8.47±2.02a,b,c | 116.45±45.04a,b,c | 5.62±2.23a,b,c |
si-Smad7 | 938.25±120.02a,b,c | 31.30±2.02a,b,c | 356.40±11.22a,b,c | 9.83±1.00a,b,c |
miR-20b-5p inhibitors + si-Smad7 | 733.17±110.23a | 11.39±2.00a | 270.40±11.22a | 7.90±1.00a |
P<0.05, compared with the sham group;
P<0.05, compared with the IR group;
P<0.05, compared with the miR-20b-5p inhibitors + si-Smad7 group. LVEDD, left ventricular diastolic diameter; LVESD, left ventricular systolic diameter; LVEDV, left ventricular end-diastolic volume; LVESV, left ventricular end-systolic volume; IR, ischemia-reperfusion; NC, negative control; miR-20b-5p, microRNA-20b-5p; Smad7, small mothers against decapentaplegic homolog 7; si-, small interfering RNA.