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. 2018 May 11;42(2):905–918. doi: 10.3892/ijmm.2018.3672

Figure 2.

Figure 2

BCL2L12 L213A is associated with reactivation of caspase-3 and the BCL2 family protein expression profiles are different in T98G and U87MG cell lines. (A) The protein expression levels of apoptotic markers and BCL2 family proteins were detected by western blotting. (B) Quantitative plot of cleaved PARP and cleaved caspase-3, (C) prosurvival proteins BCL-XL, Mcl-1, and BCL2, and (D) proapoptotic BCL2 family proteins expression in two glioma cell lines. All target protein expression levels were normalized to β-actin expression prior to conversion into fold increase measurements. *P<0.05 and **P<0.01 compared with WT group. BCL2L12, BCL2-like 12; BCL2, BCL2 apoptosis regulator; PARP, poly-ADP-ribose-polymerase; BCL-XL, BCL-extra large; Mcl-1, induced myeloid leukemia cell differentiation protein MCL-1; WT, wild-type; Bax, BCL2 associated X; Puma, BCL2-binding component 3; Bok, BCL2-related ovarian killer protein; Bim, BCL2-like 11.