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. 2018 May 11;42(2):905–918. doi: 10.3892/ijmm.2018.3672

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Copyright: © Chu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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TMZ treatment downregulates Mcl-1, creating a desirable microenvironment for applying ABT-737. (A) The expression levels of prosurvival BCL2 family proteins were detected in different experimental groups of U87MG cells by western blotting. (B) Quantitative plot of BCL-XL, BCL2 and Mcl-1 expression in the different groups. ^**P<0.01 compared with control. TMZ, temozolomide; Mcl-1, induced myeloid leukemia cell differentiation protein MCL-1; BCL2, BCL2 apoptosis regulator; BCL-XL, BCL-extra large; BCL2L12, BCL2-like 12; STS, staurosporine; GFP, green fluorescent protein; WT, wild-type.