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. 2018 May 11;42(2):905–918. doi: 10.3892/ijmm.2018.3672

Figure 8.

Figure 8

Inhibition of TMZ-induced autophagy by 3-MA leads to enhanced activation of apoptotic markers and p53 expression in U87MG cells. (A) The expression levels of apoptotic markers, autophagic markers, p53 and BCL-XL were detected by western blotting. (B) Quantitative plot of cleaved PARP and cleaved caspase-3 expression levels. (C) Quantitative plot of LC3B-II, Beclin-1, p53, and BCL-XL expression levels. *P<0.05 and **P<0.01 compared with TMZ alone. TMZ, temozolomide; 3-MA, 3-methyladenine; p53, tumor protein p53; BCL-XL, BCL-extra large; PARP, poly-ADP-ribose-polymerase; LC3B, microtubule associated protein 1 light chain 3B.