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. 2018 May 11;42(2):946–956. doi: 10.3892/ijmm.2018.3670

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Therapeutic efficacy of HO-1-BMSCs in rats with ischemia/reperfusion-induced acute kidney injury. (A) Pathological images of periodic acid-Schiff staining in the model group (×200 magnification). The model group exhibited severe renal tubular necrosis. The blue letters indicate the following features: a, rush border loss; b, vacuolar degeneration; c, epithelial cells sloughed off into the tubular lumen; and d, regenerated tubular cells. (B) ATN scores. BMSC implantation decreased the ATN score, with the lowest score in the HO-1-BMSCs group. Results are presented as the mean ± standard deviation (n=10 rats). ^aP<0.05 vs. model group; ^bP<0.05 vs. BMSCs group. HO-1, heme oxygenase-1; BMSCs, bone marrow-derived mesenchymal stem cells; ATN, acute tubular necrosis; eGFP, enhanced green fluorescent protein.