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. 2018 May 2;42(2):821–830. doi: 10.3892/ijmm.2018.3652

Figure 1.

Figure 1

Differential expression of ANX2 and intrinsic TNC in murine pancreatic neoplastic cell lines. (A) Expression levels of ANX2 in various established murine pancreatic neoplastic cell lines derived from pancreatic intraepithelial neoplasia cells (KC), primary PDAC (KPC1 and KPC2) and PDAC liver metastases (KPCLiv) were determined by western blot analysis. (B) Expression levels of ANX2 and intrinsic TNC in KC and KPC1 cells treated with control and ANX2 siRNAs were determined by western blot analysis. (C) Comparison of expression levels of ANX2 and E-cadherin with or without rTNC treatment between KC cells treated with control and ANX2-specific siRNAs. (D) Comparative analysis of expression of E-cadherin with or without rTNC between KC cells treated with control and ANX2 siRNAs. The band intensities were normalized to that of β-actin. Experiments were performed at least three times. Error bars represent the standard the error of mean. PanIN, pancreatic intraepithelial neoplasia PDAC, pancreatic ductal adenocarcinoma; ANX2, annexin II; TNC, tenascin C; siRNA/si, small interfering RNA; rTNC, recombinant TNC; NS, not significant.