Table 4.
Mean Change in IBS-SSS from Baseline and Patient Satisfaction
| Per Protocol | Intent-To-Treat | |||||
|---|---|---|---|---|---|---|
| Condition | Immediate | 3 Month | 6 Month | Immediate | 3 Month | 6 Month |
| IBS-SSS | ||||||
| MC-CBT | −89.35 ±17.0 | −105.9 ±17.7 | −111.3 ±17.9 | −80.69 ± 15.9 | −95.27 ± 16.7 | −99.09 ±17.0 |
| S-CBT | −80.99 ±17.0 | −103.2 ±16.4 | −103.5 ±17.7 | −67.57 ± 15.3 | −87.10 ± 15.3 | −85.16 ± 16.4 |
| EDU | −84.43 ±14.6 | −88.53 ±14.6 | −97.93 ±15.4 | −78.88 ± 14.3 | −82.19 ± 14.2 | −91.37 ± 14.9 |
| MC-CBT – S-CBT | −8.39 ±24.0 | −2.71 ±24.2 | −7.74 ± 24.9 | −13.11 ± 22.1 | −8.16 ± 22.7 | −13.93 ± 23.6 |
| MC-CBT – EDU | −4.95 ±22.4 | −17.41 ±22.9 | −13.34 ±23.4 | −1.81 ± 21.4 | −13.08 ± 21.9 | −7.72 ± 22.6 |
| S-CBT – EDU | 3.44 ±22.4 | −14.70 ±22.0 | −5.60 ±23.1 | 11.31 ± 21.0 | −4.91 ± 21.0 | 6.21 ± 22.4 |
| MC-CBT – S-CBT CI | −32.4 to 15.6 | −26.9 to 21.5 | −32.7 to 17.2 | −35.2 to 9.0 | −30.8 to 14.5 | −38.0 to 9.7 |
| Patient Satisfaction | ||||||
| MC-CBT | 28.9 ± 0.6 | - | - | - | - | - |
| S-CBT | 28.4 ± 0.7 | - | - | - | - | - |
| EDU | 26.6 ± 0.9 | - | - | - | - | - |
| MC-CBT – S-CBT | 0.70 ± 1.0 | - | - | - | - | - |
| MC-CBT – EDU | 2.27 ± 1.0** | - | - | - | - | - |
| S-CBT – EDU | 1.79 ± 1.1** | - | - | - | - | - |
| MC-CBT – S-CBT CI | −0.3 to 1.6 | - | - | - | - | - |
notes:
*
p < 0.05; mean IBS-SSS at baseline across conditions = 281.9 with a margin of error of ± 7.4; all changes from baseline are statistically significant, p < 0.01; Unadjusted standard deviations for IBS-SSS change scores at each time point are about 19.0, indicating substantial standardized effects (Cohen’s d) relative to baseline; MC-CBT - S-CBT CI = 95% CI for difference; Cohen’s d for patient satisfaction for MC-CBT-EDU = 0.53 and for S-CBT- EDU = 0.37; numbers after ± are margins of error (half widths of 95% CIs