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Wolff/Cope solvent studies of substrate 48
| |||
|---|---|---|---|
| entrya | solvent | dielectric constant (ε) | 50 : 51b |
| 1 | MeCN | 37.5 | 1 : 4 |
| 2 | DCE | 10.4 | 1 : 2.8 |
| 3 | THF | 7.58 | 1 : 1.1 |
| 4 | EtOAc | 6.02 | 1 : 1.3 |
| 5 | toluene | 2.38 | 1.1 : 1 |
| 6 | 1,4-dioxane | 2.21 | 1 : 1.7 |
| 7 | methylcyclohexane | 2.02 | 3 : 1 |
| 8 | heptane | 1.92 | 3 : 1 |
α-Diazoketone 48 was consumed in all reactions.
Ratios determined by 1H NMR analysis of crude reaction mixtures.
