Table 2.

Improvements of the symptoms of the Greene Climacteric Scale in score values (per protocol population with n = 86 patients in the soy group and n = 90 patients in the placebo group)

	Baseline		Week 12		Week 24
Item	Soy	Placebo	Soy	Placebo	Soy	Placebo
1. Tachycardia/palpitations	1.31 ± 0.88	1.33 ± 0.97	0.55 ± 0.64*	0.97 ± 0.93	0.31 ± 0.62	0.28 ± 0.58
2. Feeling tense or nervousness	1.97 ± 0.83	1.88 ± 0.93	0.56 ± 0.75*	1.60 ± 1.09	0.56 ± 0.83	0.37 ± 0.59
3. Difficulty in sleeping	2.22 ± 0.95	2.13 ± 0.93	0.60 ± 0.94*	1.90 ± 1.10	0.50 ± 0.90	0.43 ± 0.85
4. Excitable	1.98 ± 0.91	2.01 ± 0.93	0.62 ± 0.86*	1.74 ± 1.14	0.53 ± 0.89	0.37 ± 0.57
5. Panic attacks	1.45 ± 1.13	1.27 ± 1.27	0.30 ± 0.69*	1.21 ± 1.24	0.27 ± 0.62	0.11 ± 0.35
6. Difficulty in concentrating	1.93 ± 0.98	1.67 ± 1.04	0.53 ± 0.81*	1.63 ± 1.16	0.47 ± 0.71	0.37 ± 0.61
7. Feeling tired or lacking energy	1.92 ± 0.91	1.67 ± 0.95	0.58 ± 0.83*	1.77 ± 1.13	0.41 ± 0.64	0.32 ± 0.58
8. General loss of interest in most things	1.26 ± 1.04	1.28 ± 1.02	0.42 ± 0.64*	1.33 ± 1.16	0.38 ± 0.71	0.22 ± 0.47
9. Feeling unhappy or depressed	1.57 ± 1.11	1.62 ± 1.11	0.37 ± 0.67*	1.49 ± 1.27	0.36 ± 0.65	0.20 ± 0.48
10. Crying spells	1.01 ± 0.98	0.99 ± 0.95	0.22 ± 0.52*	1.00 ± 1.06	0.24 ± 0.68	0.30 ± 0.55
11. Feeling perturbed (inner tension)	1.92 ± 1.01	1.80 ± 0.96	0.53 ± 0.79*	1.74 ± 1.14	0.45 ± 0.73	0.37 ± 0.57
12. Feeling dizzy or faint	1.07 ± 0.86	0.87 ± 0.94	0.51 ± 0.72*	0.89 ± 0.92	0.31 ± 0.56	0.26 ± 0.55
13. Pressure or tightness in head or body	1.09 ± 1.04	0.87 ± 0.97	0.43 ± 0.66*	0.84 ± 0.94	0.26 ± 0.46	0.14 ± 0.38
14. Parts of body feeling numb or tingling	0.72 ± 0.95	0.60 ± 0.83	0.36 ± 0.72	0.54 ± 0.86	0.31 ± 0.67	0.16 ± 0.36
15. Headaches	1.01 ± 0.86	1.04 ± 1.02	0.48 ± 0.76*	0.90 ± 0.92	0.30 ± 0.65	0.29 ± 0.52
16. Muscle or joint pains	1.60 ± 0.96	1.56 ± 1.07	0.59 ± 0.83*	1.21 ± 1.14	0.38 ± 0.75	0.43 ±± 0.86
17. Loss of feeling in hands or legs	0.58 ± 0.90	0.74 ± 0.91	0.33 ± 0.71	0.54 ± 0.77	0.34 ± 0.76	0.09 ± 0.29
18. Breathing difficulties	0.60 ± 0.92	0.53 ± 0.84	0.26 ± 0.62	0.43 ± 0.70	0.16 ± 0.48	0.09 ± 0.29
19. Hot flushes	2.59 ± 0.66	2.58 ± 0.65	0.72 ± 0.88*	2.02 ± 1.07	0.63 ± 0.92	0.66 ± 0.84
20. Sweating at night	2.43 ± 0.78	2.32 ± 0.85	0.66 ± 0.85*	1.90 ± 1.08	0.55 ± 0.86	0.56 ± 0.82
21. Loss of interest in sex	2.08 ± 1.04	1.88 ± 1.08	0.67 ± 0.94*	1.80 ± 1.19	0.63 ± 1.02	0.41 ± 0.78

Group comparisons: *p ≤ 0.005