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. 2018 Jul 6;9:2644. doi: 10.1038/s41467-018-05062-2

Fig. 7.

Fig. 7

IMD significantly improved the survival of septic mice. a–e Kaplan–Meier survival analysis of the septic mice. a, b The mice were treated with saline, IMD40 (0.5 mg/kg) or IMDinh (1 mg/kg) 1 h before CLP surgery (short-term procedure, n = 10; or long-term procedure, n = 16) and every day for 3 days. c, d The mice (n = 20) received long-term CLP procedure treated with IMD40 at different dose (c) or timing (d). e The extended long-term CLP model using WT, IMD−/− mice, and IMD−/− mice (n = 12) rescued by IMD40 (subcutaneous injection, 0.25 mg/kg/day, 1 h before surgery and every day for 3 days). Each group was compared with the CLP-alone group, and significance was assessed by log rank test