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. 2018 Jul 6;8:10286. doi: 10.1038/s41598-018-28599-0

Figure 4.

Figure 4

Zoom view at the Adenine +1 remarking the stacking changes between cleavable and non-cleavable targets. (a) Structure comparison between I-CreI_D75N_target (blue), where Adenine follows the ideal B-DNA geometry, vs I-CreI_D75N_target-null (orange), where Adenine +1 largely is deviated with respect to the ideal B-DNA geometry. (b) Structure comparison between I-CreI_3115_target (blue), where Adenine follows the ideal B-DNA geometry, vs I-CreI_3115_target-null (orange), where Adenine +1 largely is deviated with respect to the ideal B-DNA geometry.