Table 1.

Univariate and multivariate analysis of factors associated with overall survival and relapse-free survival

Variables	OS				RFS
	Univariate	Multivariate			Univariate	Multivariate
	p	HR	95% CI	p	p	HR	95% CI	p
Model 1
Age, y (>50/≤50)	0.976				0.289
HBsAg (present/absent)	0.883				0.047	1.649	1.057–2.572	0.028
AFP, ng/mL (>25/≤25)	<0.0001	1.536	1.126–2.095	0.007	0.002	1.277	1.004–1.625	0.046
Tumour size, cm (>5/≤5)	0.001	1.04	0.765–1.414	0.801	0.006	1.062	0.831–1.358	0.631
Tumour number (multiple/single)	<0.0001	1.329	0.928–1.903	0.121	<0.0001	1.28	0.938–1.746	0.119
Vascular invasion (present/absent)	<0.0001	3.342	2.261–4.938	<0.0001	<0.0001	2.084	1.471–2.952	<0.0001
TNM stage (III+IV/I+II)	<0.0001	1.729	1.18–2.535	0.005	<0.0001	1.394	1.008–1.928	0.045
Differentiation (III+IV/I+II)	0.447				0.512
TC-PD-L1 (positive/negative)	0.001	1.168	1.052–1.297	0.004	0.006	1.142	1.044–1.25	0.004
Model 2
Age, y (>50/≤50)	0.976				0.289
HBsAg (present/absent)	0.883				0.047	1.575	1.011–2.456	0.045
AFP, ng/mL (>25/≤25)	<0.0001	1.623	1.187–2.22	0.002	0.002	1.304	1.023–1.664	0.032
Tumour size, cm (>5/≤5)	0.001	1.063	0.781–1.447	0.699	0.006	1.081	0.845–1.383	0.535
Tumour number (multiple/single)	<0.0001	1.257	0.875–1.805	0.217	<0.0001	1.246	0.911–1.705	0.169
Vascular invasion (present/absent)	<0.0001	3.713	2.494–5.528	<0.0001	<0.0001	2.223	1.561–3.164	<0.0001
TNM stage (III+IV/I+II)	<0.0001	1.662	1.125–2.455	0.011	<0.0001	1.34	0.965–1.86	0.081
Differentiation (III+IV/I+II)	0.447				0.512
Mφ-PD-L1 (positive/negative)	0.018	0.708	0.562–0.891	0.003	0.165	0.872	0.739–1.03	0.107

Variables associated with overall survival or relapse-free survival by univariate analysis were adopted as covariates in multivariate analysis and entered into the equation by the forward selection based on likelihood ratio test.

OS overall survival, RFS relapse-free survival, HR hazard ratio, CI confidence interval, TC tumour cells, Mφ macrophage