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. 2018 Jul 6;8:10241. doi: 10.1038/s41598-018-28625-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Characterization of EhJAB1. (A) Schematic of procedure for identifying novel protein-protein interaction with co-immunoprecipitation followed by mass spectrometric analysis. (B) E. histolytica JAB1 (EhJAB1) amino acid sequence. Peptides unique to the EhJAB1 protein identified by mass spectrometry are highlighted (blue). JAMM motif (EX_nHXHX₁₀D) shown in red box. (C) Structural homology between Human JAB1 (HuJAB1) and EhJAB1. HuJAB1 (orange) was superimposed with the predicted structure of EhJAB1 (blue). (D) Multiple sequence alignment of the conserved JAMM motif of JAB1 from pathogenic parasites. Identical (green), conserved (blue), semi-conserved (pink), and non-conserved residues (red).